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Common disinfectants reduce fertility in mice

Here's the scenario: University researcher Patricia Hunt moves her lab rats from Case Western Reserve University in Ohio to Washington State University in Pullman. Suddenly, only 10 percent of the mated females get pregnant -- and a significant percentage of the resulting fetuses die late in the pregnancy. Plus, the timing of the litters doesn't match its usual pace.

Picture
Patricia Hunt
Photo/WSU

In a Q-and-A with Brendan Maher of Nature, Hunt reflected:

We saw more birth defects in the first few months of our study than we had seen in our previous 13 years at Case.

It turns out that two chemicals in a disinfectant used to clean the lab were to blame. They are the quaternary ammonium compounds ADBAC (n-alkyl dimethyl benzyl ammonium chloride) and DDAC (didecyl dimethyl ammonium chloride). Both are in something called Virex that was used to clean the lab.

It marked the second time Hunt has accidentally discovered deleterious effects of chemicals on lab animals. While still at Case in 2003, she found that a caustic floor detergent mistakenly used to clean plastic water bottles leached out bisphenol A, whose effects we have explored before.

Hunt told Nature she's concerned about the potential effect on humans:

This group of compounds acts on the cell membrane, and does a fantastic job of killing everything. But, you know, we're composed of membranes too.

Posted by at June 19, 2008 9:38 a.m.
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Comments
#140768

Posted by unregistered user at 6/19/08 10:21 a.m.

Any substance not derived from benign ingredients has the potential to harm. Even ingredients which are plant based can in concentrated or large quantities, cause damage.
We practice our household version of the precautionary principle-if we don't know that something is totally safe, we don't use it. If I cannot pronounce it, if it is not a plant or mineral based substance, or if the label has any warnings whatsoever, it is not used in our home. We clean with baking soda, vinegar, lemon juice, plain soap. lots of scrubbing & really hot water.
All our toiletries are chosen with the same guidelines. None of us wear make-up, all soaps & shampoos are the simplest possible. It's pretty simple, and saves us money too.

#140906

Posted by skeptical at 6/19/08 11:51 a.m.

I will ship her some of my field mice. I think you have to run over them with a large vehicle to kill them.

Massive trauma and cats seem to be the surefire way to be rid of them.

#141124

Posted by humyn at 6/19/08 2:57 p.m.

Same here...I'm tired on cancerous, toxic, deforming junk in my cleaning supplies. We use only biodegradable, nontoxic now...and it smells and works just as well.

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